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Members of Bipartisan Alzheimer's Study Group Announced
(Source: ASG) - Yesterday former Speaker of the House Newt Gingrich and former U.S. Senator Bob Kerrey announced the membership of a task force to develop and advance strategies to overcome Alzheimer's.
The Most Promising Alzheimer's Drugs in Developmen
(Source: Thomson Scientific) - Thomson Scientific has issued its Third Quarter "The Ones-to-Watch" report of the most promising drugs entering phases of clinical development.
Living with Alzheimer's: 'I'm Still Me'
(Source: NPR) - Charles Jackson was diagnosed with Alzheimer's in 2004, at the age of 50. He is one of several members of his family who have been stricken with the disease. This interview is his story, describing how he was introduced to Alzheimer's and the experiences he has had caring for family members with the disease and now dealing with this own diagnosis.
Dementia Ordeal Inspires Comic Film
(Source: Jewish Journal) - Tamara Jenkins knows firsthand what an overwhelming task it is to care for a parent suffering from dementia. She also knows that no matter how grave a situation might be, there are always sparks of humor surrounding it. So it's no surprise that her new film, "The Savages," addresses that very subject and does so with a healthy dose of comic perspective.
Dementia in Asian Elders
(Source: NAM) - The Hmong view dementia as a "loss of soul," Chinese call it a form of madness, and Vietnamese believe it is a sign of possession by spirits or demons.
Atrophy Rates Accelerate in Amnestic Mild Cognitive Impairment
(Source: HighWire Press) - Researchers at the Mayo Clinic in Rochester, MN, investigated the rates of brain atrophy (shrinkage) in 69 patients demonstrating mild cognitive impairment (MCI).
Cognitive Impairment and Stroke
(Source: HighWire Press) - "Vascular cognitive impairment" is a relatively new term that relates to the effects of vascular disease and brain lesions on cognition. It encompasses the complex interactions between causes, risk factors and cellular changes within the brain.
Amyloid-induced Mitochondrial Dysfunction in Alzheimer's Disease
(Source: HighWire Press) - Amyloid-beta has long been implicated in the development of Alzheimer's. A majority of research into this disease has focused on the clumping of amyloid-beta in the brain, however, recent studies have revealed amyloid-beta appearing inside brain cells, suggesting a different mechanism of neurodegenerative pathology. In this study, Case Western Reserve University scientists note that both mechanisms, extracellular and intracellular amyloid-beta deposits, induce neuronal toxicity.
Mortality Rate in Individuals 95 -100 with Dementia
(Source: HighWire Press) - Dementia is a known predictor of mortality, but few studies focus on elderly over the age of 90.
Targeting Gamma-secretase Inhibitors for the Treatment of AD
(Source: HighWire Press) - Studies provide evidence that the production and deposition of amyloid-beta peptides (Abeta) contribute to the etiology of Alzheimer's disease. Furthermore, beta- and gamma-secretases, which are responsible for the generation of Abeta, are plausible targets for Alzheimer's disease treatment.
Management of Neuropsychiatric Symptoms in Alzheimer's Disease
(Source: NCBI) - In this study, Canadian researchers investigate data relating to various treatments of neuropsychiatric symptoms of Alzheimer's disease.
Drug Therapies for Alzheimer's Disease
(Source: NCBI) - Canadian researchers reviewed results of various drug treatments for Alzheimer's disease. They report that the cholinesterase inhibitors donepezil, rivastigmine, and galantamine have demonstrated efficacy in 3- to 12-month clinical trials assessing cognitive, functional, behavioral, and global outcomes in patients with mildly to moderately severe AD. Donepezil was effective for cognitive and functional measures, but not on behavior.
Pupil Reaction to Light in Alzheimer's Disease
(Source: NCBI) - Researchers in Greece focused on changes in pupil size and mobility as a diagnostic marker for probable Alzheimer's disease.
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